Non-Hodgkin's Lymphoma is a common complication of AIDS, including Burkitt's Lymphoma in developed countries is clear. In USA, Burkitt's Lymphoma is more than 1000 times more common in AIDS patients than in the general population and Non-Hodgkin's Lymphoma is the most common malignant complication of pediatric AIDS.
The impact of AIDS on the incidence of Non-Hodgkin's Lymphoma and Burkitt's Lymphoma in African countries is much less clear, due to the lack of reliable incidence data.The strength of the association between AIDS and Burkitt's Lymphoma in the West indicates that some increase in incidence in Africa is likely although there are indication that the increase in Non-Hodgkin's Lymphoma is less marked, at least in adults, than in the West.
This may be due to under-ascertainment of cases, different etiological factors or the earlier death of AIDS sufferers in Africa.The authors point out that Burkitt's Lymphoma is most common in rural areas of African where HIV infection is less prevalent and less common in the cities, where there is more HIV positive. They also suggest that children with AIDS from rural areas may be less likely to be referred to city hospitals than children already resident in city.
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